Search on:
DOSAGE COMPENSATION, GENETIC
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Dosage Compensation, Genetic
Descriptor
Spanish
:
Compensación de Dosificación (Genética)
Descriptor
Portuguese
:
Compensação de Dosagem (Genética)
Synonyms
English
:
Dosage Compensation (Genetics)
Tree Number:
G05.355.315.203.249
Definition
English
:
Genetic mechanisms that allow GENES to be expressed at a
similar
level irrespective of their
GENE DOSAGE
. This term is usually used in discussing genes that lie on the
SEX CHROMOSOMES
. Because the
sex chromosomes
are only partially homologous, there is a different copy number, i.e.,
dosage
, of these genes in males vs. females. In
DROSOPHILA
,
dosage
compensation
is accomplished by hypertranscription of genes located on the
X CHROMOSOME
. In
mammals
,
dosage
compensation
of
X chromosome
genes is accomplished by random
X CHROMOSOME INACTIVATION
of one of the two X
chromosomes
in the
female.
Indexing Annotation
English
:
do not confuse with
GENE DOSAGE
History Note
English
:
2006 (1982)
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
27989
Unique Identifier:
D004303
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS